ギャンブル還元率

Contact Access Sitemap Japanese Font Size Medium Large Extra Large About NIBIOHN Research and Activities Contact Links Home > Research and Activities > Laboratory of Medicinal Plant Screening Laboratory of Medicinal Plant Screening 1. Members Project leader YOSHIMATSU Kayo Sub-project leader FUCHINO Hiroyuki Researcher KAWANO Noriaki, MATSUO Hirotaka Technical staff KAWAKAMI Hitomi 2. Background and objectives The field of drug discovery has recently undergone some major changes with the introduction of new techniques such as genomic drug discovery. Accordingly, many methods that utilize natural products for drug development have become obsolete. However, in modern drug discovery techniques such as high-throughput screening, naturally occurring compounds, especially those of plant origin, are still highly applicable, as plants have the ability to biosynthesize compounds with unique chemical structures. For this reason, natural products remain important. In this Project, we are constructing a large-scale extract library based on plant resources in Japan and abroad, for use in screening for various biological activities in the context of drug discovery. 3. Overview of our research Recently, the methodologies for drug discovery have undergone remarkable changes. However, low-molecular weight synthetic compounds have been regarded as the foundation of modern drug discovery techniques, such as combinatorial chemistry and high-throughput screening (HTS). These molecules remind us of the importance of naturally occurring compounds, especially those of plant origin. Several large chemical libraries have been established domestically; by contrast, crude extract libraries have been limited to those containing materials of microorganism or marine origin. In particular, the creation of a plant origin extract library is difficult due to the highly specialized nature of plant identification. The Research Center for Medicinal Plant Resources in NIBIOHN has three experimental stations in Japan, allowing the collection of plant resources over a wide domestic area. The Medicinal Plant Screening Project hopes to facilitate drug discovery using a plant extract library as a tool for the evaluation of a wide range of biological activities, under collaboration agreements with many research institutes. In this project, we are aggressively collecting plant materials in Japan to enhance our plant extract library. More than 15,000 varieties of plant extracts are available for biological screening. This extract library also contains about 1,000 crude drugs used in Kampo medicine prescriptions. Also, to add to the fundamental information regarding this library, acquisition of endotoxin tests for each sample are currently underway. Information regarding "the borderline of pharmaceuticals to non-pharmaceuticals in Japan" and "the food history of the world", as these topics relate to the botanical origins of the materials in the plant extract library, will be appended to address inquiries and interests arising from health food companies. In addition, this project will develop an effective methodology for identification of bioactive principles from multicomponent plant extracts using LC/MS analysis. To date, active anti-HCV compounds and components of fern active against knee osteoarthritis have been identified from this plant extract library. Laboratory of Medicinal Plant Screening E-mail yoshimat*nibiohn.go.jp (replace * by @) Research and Activities List NIBIO National Institute of Biomedical Innovation Coordination Office of Research Ethics Department of Research Support Center for Intractable Diseases and ImmunoGenomics (CiDIG) Laboratory of ImmunoGenomics Laboratory of Precision Immunology Platform of Therapeutics for Intractable Disease Laboratory of Rare Disease Information and Resource Library Reverse Translational Research (RTR) Project --> KAGAMI Project --> Microbial Research Center for Health and Medicine Laboratory of Vaccine Materials Laboratory of Infectious Medical Information Laboratory of Infectious Diseases and Immunity Laboratory of Cell Vaccine Laboratory of Gut Environmental System Laboratory of Gut Microbiome for Health Center for Drug Design Research Laboratory of Proteomics for Drug Discovery Laboratory of Antibody Design Laboratory of XNA Screening and Design Laboratory of Drug Discovery Imaging Laboratory of Nuclear Transport Dynamics Laboratory of Advanced Biopharmaceuticals Laboratory of Clinical and Analytical Chemistry Laboratory of Biofunctional Melecular Medicine Artificial Intelligence Center for Health and Biomedical Research Laboratory of Bioinformatics Laboratory of In Silico Design Laboratory of Toxicogenomics Informatics AI Nutrition Project Center for Drug Discovery Resources Research Laboratory of Drug Discovery Resources Research Laboratory of Cell Model for Drug Discovery Laboratory of Functional Organoid for Drug Discovery Laboratory of Drug Discovery Resources Research Collaboration Promotion Office Laboratory Animal Resource Bank (LARB) Research Center for Medicinal Plant Resources Tsukuba Primate Research Center Section of Laboratory Equipment Section of Laboratory Animals NIHN National Institute of Health and Nutrition Department of Nutritional Epidemiology and Shokuiku Section of the National Health and Nutrition Survey Section of Nutritional Epidemiology Section of Dietary Guidelines Department of Physical Activity Research Section of Behavioral Physiology Section of Exercise Guideline Section of Healthy Longevity Researches Department of Clinical Nutrition Section of Nutritional Therapy Department of Nutrition and Metabolism Section of Energy Metabolism Section of Chrononutrition Department of Food Function and Labeling Section of Food Component Analysis Section of Food Safety and Function Section of Information Network of Health Food International Center for Nutrition and Information Section of International Nutrition Strategy Section of Population Health Metrics Section of Global Disaster Nutrition Section of Research Collaboration and Partnership AI Nutrition Research team © National Institutes of Biomedical Innovation, Health and Nutrition. 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